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Obesity is part of the phenotype of many genetic syndromes, notably over 20 Mendelian disorders (Chung and Leibel, 2005; Farooqi, 2005) (Table 15.1). Most of these are characterized by morbid obesity that begins in childhood, together with speci c dysmorphic or developmental features. These disorders, and their diagnosis and management, are discussed in detail in 21. The most common inherited syndrome is Prader-Willi syndrome (PWS), with early-onset hyperphagia and obesity, short stature, hypogonadism, poor muscle tone and learning dif culties (see Figure 21.9 on page 517). Many of the other syndromes are also characterized by neurodevelopmental delay, organ-speci c abnormalities and dysmorphic features (Table 21.2 on page 523). Several monogenic obesity syndromes, due to mutations affecting the peripheral and central pathways that regulate body fat mass, have now been recognized (Mutch and Cl ment, 2006). These include mutations affecting the genes encoding leptin, the leptin receptor, and the melanocortin-4 receptor (MC4-R) (see Figures 21.10 and 21.11 on page 519). These typically present with childhood-onset hyperphagia and severe obesity. Overall, they are very rare, although MC4-R mutations may account for 4 6% of cases of morbid obesity that begin in childhood.

This backup schedule is pretty full so you should probably start thinking about other strategies to use if your database continues to grow. For example, you might need to perform some backups during peak hours (naturally during the off-peak peak hours) or you could partition the database so areas handling different time zones are stored separately so you can back them up separately.

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By separating the harmonics in a way similar to what has been done for eq. (1.74), eq. (1.113) becomes a system of equations: C dVn (t) Is + jn 0 C Vn (t) + Ig,n (t) + (t) = 0 dt 2 n = , . . . , 0, . . . , (1.114)

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The publish/subscribe (pub/sub) domain uses destinations known as topics for sending and receiving messages. (See Figure 8-2.) A publisher sends messages to a topic and applications interested in those messages must subscribe to the topic so that the provider will push messages to them. The publisher(s) may deliver one or more messages to a topic and a topic may have zero, one, or more subscribers. Unlike a point-to-point configuration, the topic destination doesn t hold messages unless it is specifically told to do so by means of a durable subscription. A durable subscription tells the provider to hold messages for a subscriber who is offline.

Interior Gateway Protocol (IGP) A routing protocol that operates within an AS. RIP and OSPF are IGPs. Exterior Gateway Protocol (EGP) BGP is often called an EGP, although the EGP protocol was the predecessor to BGP for IP routing between autonomous systems. Static routing IP routing information that is manually con gured on a node by a system administrator. Dynamic routing IP routing information that is learned by the node through a routing protocol, such as RIP.

7. Connect the IDE connector cable to the back of the hard drive. The cable should snap into the connector without force. 8. Insert the power connector to the drive. Figure 7-5 shows both the connectors in place. 9. Finally, position the hard drive where the screw holes are aligned with the spaces in the drive bay. Use the screws provided and secure the drive. Before putting the case back on the PC, you can reconnect the power cable and start your computer. If the installation is a success your computer will start and you can go the My Computer control panel and see your new D drive on the menu. If you don t, review your steps and jumper settings and try again. 10. If the drive is present and operating, copy a few les to it and try opening them. If everything is working, shut down the computer and reattach the cover. You now have successfully upgraded your storage.

Video adaptor options On-board video adaptors AGP PCI Express 2-D/3-D GPU speed Memory Multi-monitor support Additional video adaptor features Monitor choices

In the second half of the chapter you built a member viewer application that was capable of listing all the members in the fictional book club database, as well as viewing detailed information about each member. In the process you worked with abstract classes, saw how to create classes to deal with database table access, learned some more useful features of PDO such as prepared queries, and discovered how to use MySQL s SQL_CALC_FOUND_ROWS keyword to help you display table contents over several pages. You now have a solid grounding in how to construct queries and communicate with MySQL from your PHP scripts. The next chapter takes things further and looks at how to manipulate data in a database from within PHP. Meanwhile, try the following two exercises, which test both your SQL query skills and your PHP programming skills. You can find the solutions to these exercises in Appendix A.

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